InsuGen is a next-generation metabolic support formulation built around Dihydroberberine, a superior, highly bioavailable derivative of berberine, combined with BioPerine® (piperine) to enhance absorption and maximise efficacy. This advanced core is supported by a synergistic blend of botanical extracts traditionally used to support glucose metabolism and insulin function.
Dihydroberberine represents a significant advancement over conventional berberine, offering substantially improved oral bioavailability and cellular uptake. Once absorbed, it is rapidly converted into active berberine within the body, allowing for enhanced metabolic effects at lower doses. Mechanistically, Dihydroberberine activates AMP-activated protein kinase (AMPK)—a central regulator of energy metabolism—supporting glucose uptake, improving insulin sensitivity, and assisting in the maintenance of normal blood glucose levels.
The inclusion of BioPerine® (Piper nigrum extract standardised to piperine) plays a critical role in enhancing the bioavailability of Dihydroberberine and other phytochemicals in the formulation. Piperine has been shown to increase intestinal absorption and reduce metabolic degradation of active compounds, thereby improving systemic exposure and overall efficacy.
Supporting this core system are several well-characterised botanicals:
Salacia reticulata, which supports carbohydrate metabolism by modulating digestive enzyme activity and reducing glucose absorption
Cinnamomum spp. (Cinnamon), associated with improved insulin receptor function and glucose uptake
Gymnema sylvestre, known for its role in reducing sugar absorption and supporting pancreatic function
Momordica charantia (Bitter Melon), providing insulin-mimetic compounds such as charantin
Pterocarpus marsupium, traditionally used to support glycaemic control and pancreatic health
This multi-pathway approach supports:
Healthy insulin sensitivity and glucose utilisation
Maintenance of normal blood glucose levels
Efficient carbohydrate metabolism
Reduced postprandial glucose fluctuations
Optimised absorption of key metabolic actives
InsuGen is particularly suited for individuals requiring targeted metabolic support, where bioavailability and efficacy of active compounds are critical to achieving consistent outcomes.